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If I'm willing to use a 45 or a 9mm, wouldn't 300 sub be an improvement, especially with a can?
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Depends on the parameters and bullets used.
Subsonic, super short (HD) distance only?
Better than 147's and almost as good as 230's, but an absolute fuck-ton more expensive to shoot in order to good expanding bullets.
I think the biggest benefit would that 300blk won't be blow-back operated, and is a native small frame round. Plus there are currently 300blk subs that defeat IIa armor and bulletproof glass.
If there is a non-expanding 190gr 300blk sub that penetrates IIIa however, that is an interesting development and really increases the capability portfolio of the caliber.