Quoted:
That looks like a good way to get stung.
Former exterminator here. 100's of nests obliterated, haven't been stung once. Well...as a kid, but I stepped on the bugger, so I kinda deserved it.
If you've got a nest, wait until dusk or just after, when it starts to cool down. Most of the wasps/hornets will be home then, so you can eradicate them effectively. There'll probably be a few stragglers that'll come back, but if you work quickly you'll get most (if not all) of them.
Your local hardware store has a spray foam wasp killer. Buy one. One of them should do 2-4 nests, depending on the size.
First thing you do is spray the exit hole. The foam will expand and block their exit. Any wasps trying to leave the nest will get covered in the poison and drop to the ground, writhing in their final moments of tortured life.
Now, put the nozzle on. It's that little red straw like you find on a can of WD40. Jab the nest with it like you're giving it an injection. Which you are. An injection of death.
Start spraying, and slowly pull the nozzle out of the nest. This'll make sure that the foam expands into each section of the nest, killing everything inside.
Once the nozzle is free of the nest, take it off and use the wide spray to kill off any stragglers. Go have a beer and celebrate a job well done. When your beer is done, go back outside and look at the genocide you've committed. The corpses of your victims will be laying on the battlefield, and you will stand victorious. Unleash your victory roar now, standing above the ruined bodies of those who would have encroached on your domain. You are truly a magnificent beast of battle. You have become death. The destroyer of worlds.