When I broke my ankle, I "discovered" 2 things, one bad, one sorta bad.
I discovered that my naturally high tolerance for pain has a very finite limit.
I also discovered that I am remarkably resistant to drugs.
In the ER, they gave me a shot of dilla-somethingorother and stood there like they expected me to go out or at least relax. It made me feel warm and like I needed to piss, but my ankle still REALLY hurt. The nurse was very shocked that the first dose did little, and the second dose (that, according to her would knock out an elephant) was barely sufficient.
After surgery, They had me on the max dosage of hydrocodone and then had to prescribe Tramadol to supplement. The doc seemed to worry that he was going to have to taper me off both when we talked about it being time to quit, and was very surprised that I had quit both cold turkey a couple days prior with not much more than some chills and a flu-like feeling for a few hours.