No love for Texas Pete's or Frank's??? Wtf is wrong with you people and your hipster brand, flaming bunghole hot sauces? Texas Pete is the best for a good southern fried chicken, runny egg, and pimento cheese biscuit sandwhich. Franks, well, I can put that s*** on anything.
I like the Tobasco Chipotle stuff they have at Chipotle restaurants. Has a nice sweet and smokey profile to tone down the vinegar base. Regular Tobasco is no good to me.
There's a local Mexican restaurant chain in the Chicagoland/NW Indiana area called Pepe's. They bottle their own hot sauce and it blows away anything else you've ever had for Mexican food. Valentina's doesn't even come close. If you're in the area, find a Pepe's and walk in just to grab a few bottles even if you don't go to eat there. It'll be worth the trouble.
Louisiana Hot Sauce is also really good with certain things like in bean soup.
I'd be open to other hot sauces that have delicious flavor profiles, but definitely don't want something that is too hot and ruins the food it's on. Just haven't come across any yet.