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If done wrong it will be just like the other 5 attempts
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Yep.
Although, to be honest - the book really isn't that great. The overall story is good, most characters are good... it's the execution that's not so great.
It starts out fantastic - the young prince of a great house in mortal conflict with a twisted enemy, a new planet with hidden dangers.
Then at some point, Herbert got swept up in the whole late 60's "Islam is cool" trend, and decides to turn Paul into the 2nd coming of Moses or whatever.
So the last 1/4 or so of the book is a big leap forward - Paul is no longer the young man who has to prove himself to his new tribe; he's now the fucking Messiah. Suddenly, the new sand Jesus and his simple desert people morph into a mighty Jihad who overcome the Imperial forces and seize not only the planet, but the entire Empire. All because they control the magic spice.
IMO, Herbert should never have written the sequels (which are progressively worse - by the time the reader gets to Chapterhouse Dune, a guy feels like he's been locked in a nunnery and forced to read Italian opera scripts). He should have turned the first novel into a trilogy, and taken more time to develop all the crap that happens in the last couple chapters of Dune.
Plus, really? If the damn spice was the key to all power in the galaxy, wouldn't the Emperor control it directly? Perhaps using his legions to secure and protect the hoard? And not leave it in the hands of the obviously devious Harkonnens or the honorable-yet-inept
Ned Stark Duke Leto?
After carefully re-reading the book recently, I think the problem is - Herbert didn't start out with the intention of making the spice the equivalent of The Force... he just ended up there as a result of the acid trip orgies that spring forth in the 2nd half.