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4/27/2023 10:45:01 AM EST
[#1]
Quote History
Quoted:
If you move more and eat less garbage you are likely to lose weight, allegedly.
View Quote


that’s racist

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4/27/2023 10:53:18 AM EST
[#2]
I've seen the future...
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4/27/2023 10:59:51 AM EST
[#3]
Quote History
Quoted:
I heard that these drugs have to be taken forever. If one stops taking it, instantly fat again and very unhealthy. Also, I thought being a fucking beached whale was healthy and popular now
View Quote

I think it's because people go back to bad habits.

I had put on a few pounds over the holidays. I closely watch my weight and this reached a point of being distressing. I had slowly changed my eating habits, adding a small snack at night, which I never used to do.

I think the biggest factor was losing my olive oil spoon. I get special olive oil, right from the people that press the olives and bottle it. It's not sold in stores, and you can request the yearly certificate of analysis. It's very high in polyphenols and a bunch of other stuff I can't spell. It tastes like olive oil, not the stuff Americans call olive oil that is so cut with canola oil it's tasteless.

But I digress. I order enough for most of the year in December, which is right after harvest when it's bottled.

My lunch is a master salad with all the super nutritious vegetables, berries, flax seed, turmeric, etc. I use my olive oil spoon to portion the correct amount. Since I lost that spoon I was eyeballing it. Imagine my surprise when I was down to 2 small bottles. I consumed 6 or 7 months of olive oil in 2 months. On the plus side, my blood work has never been better. Even my WBC went up! I'm usually severely neutropenic so this was a shock. Same with lipid profile.

Weight is another story, gained about 10 pounds...   That's a lot for an old woman so I started measuring my oil again ( seemed like such a small amount compared to what I got in the habit of dumping on).

I went back to my habits but I'm old, I could maintain my new weight but not lose it. Contrary to GD I walk a lot, ride a bike, do yard work and get as much exercise as old cartilage will let me.

I got an ozembic sample at the doctor office. I didn't use it right away but a few weeks ago I started. Finally the scale is going down!! Yay!!

I only have one scringe, I'm not planning on getting more. It will be interesting to see if I gain the weight back.

I don't think I will, I'm not morbidly obese and even though I've gained weight my BMI says I'm not too fat. I've had no side effects. I can vouch that it makes you feel full. I think I can stretch the dosed to over one weekly, the effects persist more than one week.

This is an opportunity to re-calibrate my habits. I'm a creature of habit so I think this will work. Wish me luck. I have some form fitting hiking shorts that require I knock off a few pounds to wear comfortably.

If I fail I will be sure to post about it so GD can rake me over the coals.
4/27/2023 11:01:38 AM EST
[#4]
Quote History
Quoted:

This is how I've heard it explained from everyone I know taking it. You just never feel hungry, and you feel full as soon as you eat a little.
View Quote

That's been my experience, which was how I felt before I overindulged over the holidays. Adding treats made me have cravings. Also olive oil.
4/27/2023 11:02:18 AM EST
[#5]
I thought being fat was healthy and brave now..?
4/27/2023 11:04:44 AM EST
[#6]
My insurance does not cover it for weight loss only.. so if i wanted to take it, its $1400 every two months.  I think with coupons and stuff you an get it down to a $1000.
4/27/2023 11:04:53 AM EST
[#7]
They are finding out more about these GLP-1 drugs as the years go on.   Cravings for alcohol and even tobacco are reduced for some.
Losing weight can have a profound positive effect on bloodwork.   I’ve heard of men that said after loosing weight their joints hurt less and other health concerns went away.

Look at LLY NVO VKTX quote and charts. (NOT A RECOMMENDATION, do your own damn research and speak to a licensed professional.)
4/27/2023 11:07:37 AM EST
[#8]
Government needs to mandate veggies & crickets for tubbies!
Fat is not climate green.
Eatin for two or three people should be banned!
4/27/2023 11:09:52 AM EST
[#9]
GD hates everything.

This class of medication is well understood. Medicines are just one tool in the arsenal.

The data thus far look very promising. It’ll be interesting to see the results of the recently announced head to head trials.
4/27/2023 11:11:15 AM EST
[#10]
Quote History
Quoted:
This is ridiculous.

The cure for being fat, lazy, and weak minded is to eat real food and exercise.

Offering a medication instead of exercise and a healthy diet is not addressing the actual problem.

People will use the medication, continue their shitty life choices and keep the Pharma companies flush with cash.

But, we all know that's the plan, right?

View Quote

Or - it can be used as a tool. You are assuming people don't exercise and eat right.

I'm not fat, lazy, and only somewhat weak because of arthritis. But 10 lbs can turn into 70lbs if not nipped in the bud.


For evidence read the keto thread. I enjoyed it at first but then it was just people "falling of the wagon" and gaining 100 lbs back. Why would someone do this? How did they not notice they gained 100lbs, they could have turned it around at 10lbs.

Also, just because you eat a "carb" doesn't mean you have to be a carb glutton for three months (or 100 lbs later).

There is a lot of eating disorders in that thread. Oh I've done it, it worked great. But I could have something carby every now and then and not "fall of the wagon"

In my case it really helped with inflammation from arthritis. I didn't try to make fake food that tasted like non-keto food. That doesn't change ones cravings.
4/27/2023 11:12:52 AM EST
[#11]
Quote History
Quoted:
How long until they discover it will kill you in 20 or so years? Or do they already know and it's a feature, not a bug?
View Quote

I doubt I have 20 years left so I don't care.
4/27/2023 11:13:25 AM EST
[#12]
Quote History
Quoted:
It works great at treating the symptom and not the disease. Eventually it stops working or they cant afford it anymore and they gain all the fat back, but none of the lean mass or bone density they are losing at an alarming rate.

40% of weight lost on semiglutides is lean muscle and bone density.
View Quote


IIRC Greg Doucette looked into at least one of the studies, they did lose weight, but they lost MORE lean muscle than fat.
4/27/2023 11:16:05 AM EST
[#13]
Quote History
Quoted:

I think it's because people go back to bad habits.

I had put on a few pounds over the holidays. I closely watch my weight and this reached a point of being distressing. I had slowly changed my eating habits, adding a small snack at night, which I never used to do.

I think the biggest factor was losing my olive oil spoon. I get special olive oil, right from the people that press the olives and bottle it. It's not sold in stores, and you can request the yearly certificate of analysis. It's very high in polyphenols and a bunch of other stuff I can't spell. It tastes like olive oil, not the stuff Americans call olive oil that is so cut with canola oil it's tasteless.

But I digress. I order enough for most of the year in December, which is right after harvest when it's bottled.

My lunch is a master salad with all the super nutritious vegetables, berries, flax seed, turmeric, etc. I use my olive oil spoon to portion the correct amount. Since I lost that spoon I was eyeballing it. Imagine my surprise when I was down to 2 small bottles. I consumed 6 or 7 months of olive oil in 2 months. On the plus side, my blood work has never been better. Even my WBC went up! I'm usually severely neutropenic so this was a shock. Same with lipid profile.

Weight is another story, gained about 10 pounds...   That's a lot for an old woman so I started measuring my oil again ( seemed like such a small amount compared to what I got in the habit of dumping on).

I went back to my habits but I'm old, I could maintain my new weight but not lose it. Contrary to GD I walk a lot, ride a bike, do yard work and get as much exercise as old cartilage will let me.

I got an ozembic sample at the doctor office. I didn't use it right away but a few weeks ago I started. Finally the scale is going down!! Yay!!

I only have one scringe, I'm not planning on getting more. It will be interesting to see if I gain the weight back.

I don't think I will, I'm not morbidly obese and even though I've gained weight my BMI says I'm not too far. I've had no side effects. I can vouch that it makes you feel full. I think I can stretch the dosed to over one weekly, the effects persist more than one week.

This is an opportunity to re-calibrate my habits. I'm a creature of habit so I think this will work. Wish me luck. I have some form fitting hiking shorts that require I knock off a few pounds to wear comfortably.

If I fail I will be sure to post about it so GD can rake me over the coals.
View Quote

So.....Where is the oil from?
4/27/2023 11:17:48 AM EST
[#14]
I've been on Mounjaro since November. The stuff works. All my side effects have been minor so far.
4/27/2023 11:18:57 AM EST
[#15]
A friend was on one of the drugs and it was helping her lose weight, but now it's so hard to get since everyone is wanting it, she's put weight back on since she can't get it.  

4/27/2023 11:20:23 AM EST
[#16]
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They work.

My wife and a good friend are both taking Mournjara. In 3 months, one lost 50lbs the other 30.

My wife is now having some digestive issues. Not sure if it is a side effect. Docs trying to find out. Others are reporting gall bladder stones and issues. Too early to tell.

Lose the 30, then quit.
View Quote

Gall stones can be a side effect of rapid weight loss, it doesn't matter how that loss was obtained.

My plan is to extend the doses. My second one was 8 days. My third on will be even more. The lack of hunger effect lasts longer than one week.

Never being hungry - ever - is weird. I almost have to force myself to eat. Being able to be active and not suffer weakness or anything really, in spite of the fact you haven't eaten in almost 24 hours is weird too. But then I was able to do this intermittently fasting so maybe I'm used to it.
4/27/2023 11:30:04 AM EST
[#17]
The fatter you get the stronger your food drive is, and the feeling that your not full. I even see it in cattle, just seems to be how biology is wired.
4/27/2023 11:35:46 AM EST
[#18]
Quote History
Quoted:

So.....Where is the oil from?
View Quote

My brands are Kouzini and Bariani.

Kouzini comes from Greece. They have a website you can check out. You can also email or call them. I order directly from them, don't order from Amazon.  The olive oil has a nice balance.

Bariani is from Italian trees in California. It's a very very strong tasting oil with bitter notes. That's the polyphenols talking.

They also have a website. I get the early harvest mostly. It sometimes sells out. Early harvest is made from green olives and is a little more nutritious and tastes different.

There are other companies but I've settled on these two. I order nothing from Amazon, I've gotten fake and expired oil doing that.

Olive oil is supposed to be strong spicy and peppery. Americans don't like this, that's why the stores are full of adulterated oil.

You won't find the aforementioned brands in the store because they produce a finite amount and when they're out they're out. California ranch used to be good but got popular so they started importing oils from everywhere. The brands I get come from trees from the same area. The olives are pressed within 2 hours of picking. This has a large effect on how nutritious it is.


Fake oil can be dangerous.

Check out the Spanish oil disaster


Here is one link. There are others. It's why I don't trust olive oil from unknown sources
4/27/2023 11:43:37 AM EST
[#19]
I've started it a few days ago.  No major side effects, and a small effect on hunger.  Let me do a little Q&A on it:

Q: Will you be taking it for the rest of your life?
A: Don't know yet. What I do know is that if I don't lose the weight, I will be continuing to take blood pressure medication I'm currently on -  for the rest of my life.  If I have to take medicines, I'd rather take one that lets me be normal weight and normal blood pressure versus just normal blood pressure.

Q: Won't it make you lose muscle and bone mass?  
A: Probably to some extent, just like any weight loss program.  News flash: if you are in calory-negative territory, your body attempts to preserve it's weight via catabolis.  That means you'll be losing muscle, tendons and bone mass - unless you do enough resistance training to counteract it.  This is not unique to GLP-1 drugs, this is true of any weight loss.  

Q:What if it causes cancer / Alzheimers / stroke?
A: Being overweight causes all those things as well.  Semiglutide has been on the market for 10+ years.  It's likely that anything really significant would already have surfaced.

Q: Aren't you just going to keep eating the same?
A: No.  It definitely makes you want to eat less.  That's how you lose weight on it, you eat less food.  There is some anecdotal evidence that it also makes you want to avoid some unhealthy foods, like foods heavy in fats and simple sugars.

Q: Why don't you just stop eating?
A: Why don't you get a few advanced degrees and make $250,000/yr?

4/27/2023 11:46:07 AM EST
[#20]
and when the side effects start to roll in ....
4/27/2023 11:46:30 AM EST
[#21]
Quote History
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most people going on it don't have 20 or so more years anyway LOL
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Quoted:
How long until they discover it will kill you in 20 or so years? Or do they already know and it's a feature, not a bug?


most people going on it don't have 20 or so more years anyway LOL
You're probably right.
4/27/2023 11:48:02 AM EST
[#22]
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Quoted:

Never being hungry - ever - is weird. I almost have to force myself to eat. Being able to be active and not suffer weakness or anything really, in spite of the fact you haven't eaten in almost 24 hours is weird too. But then I was able to do this intermittently fasting so maybe I'm used to it.
View Quote


I'm seeing some of that. Looking at food and having zero anticipation of eating it is both strange and very liberating.  Like I was telling my friend - nobody eats chips because they are really hungry, it's because the saltiness and crunchiness really hit the pleasure centers of the brain.  That's why you can eat them even if you're full - the enjoyment is almost entirely separate from satiation of hunger.   GLP-1 agonist seem to short-circuit that response, so that junk food no longer pushes those particular buttons.
4/27/2023 11:48:05 AM EST
[#23]
Ozempic & Other Weight Loss Drugs | Educational Video | Biolayne


The Problems with Ozempic [What the Research Shows...]
4/27/2023 11:56:04 AM EST
[#24]
Quote History
Quoted:

Q: Won't it make you lose muscle and bone mass?  
A: Probably to some extent, just like any weight loss program.  News flash: if you are in calory-negative territory, your body attempts to preserve it's weight via catabolis.  That means you'll be losing muscle, tendons and bone mass - unless you do enough resistance training to counteract it.  This is not unique to GLP-1 drugs, this is true of any weight loss.  


View Quote



Normal caloric restriction weight loss results in a loss of 1lb:4lb ratio of lean mass to adipose and no or almost no loss in bone density.

Dexa scans across several studies with semiglutide use show roughly 40% loss of muscle mass and bone density. You're getting lighter but you're getting fatter. And when you ultimately gain all that fat back your basal metabolism will be even lower than before and a solid sneeze will snap what's left of your spine.
4/27/2023 11:57:48 AM EST
[#25]
Every fat person knows how they got fat, and they know exactly what they need to do to stop being fat. They just don’t do it.

I wouldn’t fault someone for trying something new to lose weight, but pretty much every weight loss drug ever has stunk to high heaven of the pharma industry taking advantage of peoples laziness and low self-esteem.
4/27/2023 12:00:11 PM EST
[#26]
Good advice I got was to just not eat after 5PM. No other changes.

Resulted in a loss of ~10 pounds of fat per month.

It was easier to do when working 8’s, it’s difficult when I get off work after 5 and home after 6.
4/27/2023 12:01:04 PM EST
[#27]
Trulicity sucks. I refuse to take it anymore. I've asked my doc about taking the other two, she said due to supply issues, I have to wait 9 months.
4/27/2023 12:08:50 PM EST
[#28]
Quote History
Quoted:


IIRC Greg Doucette looked into at least one of the studies, they did lose weight, but they lost MORE lean muscle than fat.
View Quote View All Quotes
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Quoted:
Quoted:
It works great at treating the symptom and not the disease. Eventually it stops working or they cant afford it anymore and they gain all the fat back, but none of the lean mass or bone density they are losing at an alarming rate.

40% of weight lost on semiglutides is lean muscle and bone density.


IIRC Greg Doucette looked into at least one of the studies, they did lose weight, but they lost MORE lean muscle than fat.


Sounds like you need to combine the meds with exercise and calcium supplements, and go off the meds every other month to keep from coming out worse off than you started.

But that would require work, dedication, and lifestyle changes that folks won’t make, which is why they’re fat in the first place.

I’d challenge all the fatties like me to just change their schedule to have no meals, snacks, or sugary drinks after 5PM for a couple months, see how it goes. (For those working a normal schedule, that is)
4/27/2023 12:15:49 PM EST
[#29]
I know one thing. It/they made the profit in our stock portfolio fatter.
4/27/2023 12:17:32 PM EST
[#30]
Quote History
Quoted:

My brands are Kouzini and Bariani.

Kouzini comes from Greece. They have a website you can check out. You can also email or call them. I order directly from them, don't order from Amazon.  The olive oil has a nice balance.

Bariani is from Italian trees in California. It's a very very strong tasting oil with bitter notes. That's the polyphenols talking.

They also have a website. I get the early harvest mostly. It sometimes sells out. Early harvest is made from green olives and is a little more nutritious and tastes different.

There are other companies but I've settled on these two. I order nothing from Amazon, I've gotten fake and expired oil doing that.

Olive oil is supposed to be strong spicy and peppery. Americans don't like this, that's why the stores are full of adulterated oil.

You won't find the aforementioned brands in the store because they produce a finite amount and when they're out they're out. California ranch used to be good but got popular so they started importing oils from everywhere. The brands I get come from trees from the same area. The olives are pressed within 2 hours of picking. This has a large effect on how nutritious it is.


Fake oil can be dangerous.

Check out the Spanish oil disaster


Here is one link. There are others. It's why I don't trust olive oil from unknown sources
View Quote


Hmm. I'd always been using Kirkland organic EVOO or California Olive ranch because they tested to be genuine in 3rd party testing. But that isn't an ongoing thing...so it might have changed.

I ordered some Bariani.
4/27/2023 1:30:55 PM EST
[#31]
Im on a cut right now and I am the opposite of the reduced eating window people.  I eat 6 meals a day.  I find cuts much easier when I am eating that many meals because just when hunger really starts it's time to eat another meal.  I typically eat my first meal at 4am and my last one around 7pm.
4/27/2023 2:04:53 PM EST
[#32]
Quote History
Quoted:



Normal caloric restriction weight loss results in a loss of 1lb:4lb ratio of lean mass to adipose and no or almost no loss in bone density.

Dexa scans across several studies with semiglutide use show roughly 40% loss of muscle mass and bone density. You're getting lighter but you're getting fatter. And when you ultimately gain all that fat back your basal metabolism will be even lower than before and a solid sneeze will snap what's left of your spine.
View Quote




Weight loss, achieved through a calorie-reduced diet, decreases both fat and fat-free (or lean body) mass (44–46). In persons with normal weight, the contribution of fat-free mass loss often exceeds 35% of total weight loss (47, 48), and weight regain promotes relatively more fat gain (49). In persons who are overweight or obese, fat-free mass contributes only ~20–30% to total weight loss (48, 50–59), and weight regain does not prevent fat-free mass regain (49). Men tend to lose more fat-free mass than women, especially shortly after the initiation of weight loss (60, 61), probably because they are leaner than women (26). Diet-induced weight loss in those with obesity therefore results in a more favorable fat-free mass to fat mass ratio despite loss of lean mass, and weight cycling (yo-yo effect) has no adverse effect on body composition in persons with obesity (49).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421125/

As you can see, when normal weight people lose weight, their loss of lean body mass is practically the same as obese people losing weight on semaglutide.  I do not see this to be a major threat leading to "spine snapping".  

This media panic was sparked by Peter Attia, whom I (personally) do not find very convincing in general.  But if you do, read what he actually said:
"It’s important to note that both of these trials were conducted in adults with overweight or obesity, and higher lean mass loss among such individuals can still be an acceptable cost for dramatic weight reduction as long as overall body composition is improving. Indeed, despite the high lean mass losses, the proportion of lean mass to total body mass still increased in STEP 1 patients by an average of roughly 3% and in SUSTAIN 8 patients by an average of just over 1%."
https://peterattiamd.com/the-downside-of-glp-1-receptor-agonists/

So no, people are not "getting fatter" after using semaglutide.
4/27/2023 2:09:40 PM EST
[#33]
Wait…I do a 5K everyday are you telling me I can stop
4/27/2023 2:09:59 PM EST
[#34]
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Yay keep stuffing your face so WE can spend $500/month on drugs for the rest of your life.

Start just skipping breakfast. See how long you can wait before you are actually hungry. Stop snacking on garbage.
Cut out soda and beer.

Any one of those would work wonders for a lot of people.
View Quote



Fixed it for you.......
4/27/2023 2:14:48 PM EST
[#35]
As a member posted, this would be great for required weight loss for surgery, etc.

Long term, probably going to have some major side effects. Make sure you sell the stock before the class action lawsuit.
4/27/2023 2:28:08 PM EST
[#36]
Quote History
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Weight loss, achieved through a calorie-reduced diet, decreases both fat and fat-free (or lean body) mass (44–46). In persons with normal weight, the contribution of fat-free mass loss often exceeds 35% of total weight loss (47, 48), and weight regain promotes relatively more fat gain (49). In persons who are overweight or obese, fat-free mass contributes only ~20–30% to total weight loss (48, 50–59), and weight regain does not prevent fat-free mass regain (49). Men tend to lose more fat-free mass than women, especially shortly after the initiation of weight loss (60, 61), probably because they are leaner than women (26). Diet-induced weight loss in those with obesity therefore results in a more favorable fat-free mass to fat mass ratio despite loss of lean mass, and weight cycling (yo-yo effect) has no adverse effect on body composition in persons with obesity (49).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421125/

As you can see, when normal weight people lose weight, their loss of lean body mass is practically the same as obese people losing weight on semaglutide.  I do not see this to be a major threat leading to "spine snapping".  

This media panic was sparked by Peter Attia, whom I (personally) do not find very convincing in general.  But if you do, read what he actually said:
"It’s important to note that both of these trials were conducted in adults with overweight or obesity, and higher lean mass loss among such individuals can still be an acceptable cost for dramatic weight reduction as long as overall body composition is improving. Indeed, despite the high lean mass losses, the proportion of lean mass to total body mass still increased in STEP 1 patients by an average of roughly 3% and in SUSTAIN 8 patients by an average of just over 1%."
https://peterattiamd.com/the-downside-of-glp-1-receptor-agonists/

So no, people are not "getting fatter" after using semaglutide.
View Quote View All Quotes
View All Quotes
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Quoted:




Weight loss, achieved through a calorie-reduced diet, decreases both fat and fat-free (or lean body) mass (44–46). In persons with normal weight, the contribution of fat-free mass loss often exceeds 35% of total weight loss (47, 48), and weight regain promotes relatively more fat gain (49). In persons who are overweight or obese, fat-free mass contributes only ~20–30% to total weight loss (48, 50–59), and weight regain does not prevent fat-free mass regain (49). Men tend to lose more fat-free mass than women, especially shortly after the initiation of weight loss (60, 61), probably because they are leaner than women (26). Diet-induced weight loss in those with obesity therefore results in a more favorable fat-free mass to fat mass ratio despite loss of lean mass, and weight cycling (yo-yo effect) has no adverse effect on body composition in persons with obesity (49).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421125/

As you can see, when normal weight people lose weight, their loss of lean body mass is practically the same as obese people losing weight on semaglutide.  I do not see this to be a major threat leading to "spine snapping".  

This media panic was sparked by Peter Attia, whom I (personally) do not find very convincing in general.  But if you do, read what he actually said:
"It’s important to note that both of these trials were conducted in adults with overweight or obesity, and higher lean mass loss among such individuals can still be an acceptable cost for dramatic weight reduction as long as overall body composition is improving. Indeed, despite the high lean mass losses, the proportion of lean mass to total body mass still increased in STEP 1 patients by an average of roughly 3% and in SUSTAIN 8 patients by an average of just over 1%."
https://peterattiamd.com/the-downside-of-glp-1-receptor-agonists/

So no, people are not "getting fatter" after using semaglutide.



Here is further reading.

Article


However, from the information we can scrape together based on sub-cohort data, these “miracle drugs” start to look a bit less miraculous. In 2021’s STEP 1 trial – the first trial demonstrating the efficacy of semaglutide as a treatment for adult obesity – a subset of 140 patients underwent DEXA scans for body composition analysis. Among these patients, lean mass accounted for approximately 39% of total weight loss – substantially higher than ideal. In a substudy of 178 patients from the SUSTAIN 8 trial on semaglutide as a diabetes treatment, the average proportion of lean mass loss was nearly identical at 40%, despite lower doses and less total weight loss than in the STEP 1 trial.


As we’ve seen time and again, there are no such things as “miracle drugs,” and GLP-1 agonists are no exception to this rule. While they may have value for certain individuals, these medications come with downsides beyond their hefty price tag, and both physicians and patients ought to exercise extreme caution and discretion in determining whether they are truly the right choice for weight management.


When we take body composition into factor, these people are getting lighter, but they're getting fatter.



Dr Peter Attia, a physician based in Austin, Texas, warned the drugs were not a 'panacea' for weight loss — despite taking Hollywood by storm.

He said that they prompted equal muscle-to-fat loss in patients, which he argued made them metabolically 'fatter' because they then had a higher fat-to-muscle percentage.


Dr Attia giving a talk on it.
4/27/2023 2:28:14 PM EST
[#37]
What's wrong with good old benzedrine and dexedrine?

4/27/2023 2:31:58 PM EST
[#38]
You guys are right, back the blue bell truck up, don't subscribe to any of the voodoo except some new diet book.
4/27/2023 2:35:11 PM EST
[#39]
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It supposedly works extremely well.

My girlfriend is a plastic surgeon & general surgeon. It’s prescribed a lot more now to patients that can’t have surgeries due to weight. So that they can quickly cut weight down to have the surgery.

I guess the problem, as always, is life style changes once you go off it. Unless you correct your life style, it’s never going to work forever.
View Quote


It does. Been on Mounjaro since July. Great stuff.
4/27/2023 2:35:59 PM EST
[#40]
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It's all the rage right now with the good looking soccer moms. I know tons of people on it... and they're all a lot skinnier now.

It sounds like a miracle drug so far.
View Quote


It's amazing.
4/27/2023 2:39:35 PM EST
[#41]
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So it's meth
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I am *not* a medical expert at all. I’m just repeating what I’m told. If you’re non-diabetic and just taking it for weight loss, you can go off it.

If you’re diabetic, and you go off it, problems can happen.


It was explained to me, it basically just artificially induces the full feeling hormone.  So you naturally eat less.

But again, I am absolutely not an expect.

This is how I've heard it explained from everyone I know taking it. You just never feel hungry, and you feel full as soon as you eat a little.

So it's meth


no.  you can go off this.  not so much with meth, according to my observations anyway
4/27/2023 2:41:39 PM EST
[#42]
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Quoted:



Here is further reading.

Article


View Quote


Literally the article I linked to, earlier. Did you actually read what Peter Attia says?  In case you didn't, let me repeat:
"It’s important to note that both of these trials were conducted in adults with overweight or obesity, and higher lean mass loss among such individuals can still be an acceptable cost for dramatic weight reduction as long as overall body composition is improving. Indeed, despite the high lean mass losses, the proportion of lean mass to total body mass still increased in STEP 1 patients by an average of roughly 3% and in SUSTAIN 8 patients by an average of just over 1%."
4/27/2023 2:55:02 PM EST
[#43]
Quote History
Quoted:

Dexa scans across several studies with semiglutide use show roughly 40% loss of muscle mass and bone density. You're getting lighter but you're getting fatter. And when you ultimately gain all that fat back your basal metabolism will be even lower than before and a solid sneeze will snap what's left of your spine.
View Quote




4/27/2023 3:01:16 PM EST
[#44]
Really cool but I can't afford any of it.
4/27/2023 3:03:43 PM EST
[#45]
Quote History
Quoted:
I've been on a couple of GLP-1 agonist drugs, Victoza, Trulicity, Ozempic, etc. for the type 2 'beetus.

Super bad maternal-side genes for shitty insulin receptors is our curse. Both maternal grandparents, aunts, and my mother, now me. None are or were significant fatties.

No side-effects for me from using it, nor from going cold-turkey on them several times for months + because I can't find the stuff to fill my Rx as the fatties are all bum-rushing their doc to get them.

My average bg mg/dl gets noticeably worse, and the Metformin and supplemental insulin, and Jardiance coaxing my kidneys to pee away excess glucose doesn't pick up the slack.

Pancreantitis or actual Pancreatic cancer is a shitty way to die, but if you've got type 2, or are just a fatty, that'll kill you too. Just a matter of how fast, and the eventual odds. And GLP-1 agonist odds are way lower. Plus "you or a loved one" can't sign onto a class-action advertised on late-night TV a decade in the future, and maybe get a check for a few thousand bucks for type 2 'beetus, or for being a fatty, as there's nobody to sue.

Granted, the modern American diet & lifestyle with a big predominance of HFCS & bleached processed starch in a box/bag containing as much air as possible, because it's most amenable to industrial economy-of-scale.... Then combined without a job of back breaking labor 7/365 in a farm field, and the automobile, etc. ain't helping.

And going all Uncle Joe & Mao to fix that from beginning to end, kinda creates a "national weight loss program" for everybody, if they need it or not. Bernie bitching there's more than 2 brands of armpit sticks is bad enough.

And from the Tumblr/Reddit types that bitch about fat-cats & "failures of capitalism", mainly because their liberal arts degree, six-figure student debt, and Starbucks job didn't gain them sufficient economic utility to have a BMW & McMansion... that sort of thing doesn't require conspiracies. It's just a bunch of "path of least resistance" kind of stuff. And eating kale and a chicken breast, and not settling off the "lunk alarm" at Planet Fitness is kind of a PITA.

And your bg going way over 200 mg/dl anyway, when all you did eat was that damn 8oz chicken breast & kale for dinner, is discouraging. So the shots it is.
View Quote


Thanks for posting that.

I am a walking pin cushion.

Between the test cyp and the vitamin B (12?) complex that I inject, I am half tempted to add a third:  semaglutide.

The vials are sitting in my fridge, waiting.  I finally got them last week.

I had ordered them through my “men’s clinic” .

There was a glitch in the shipping, so they comp’ed me the vitamin B stuff.

The semaglutide might just wait.  I am kinda nervous about  taking it because like other posters have said….5 years from now, the late night ambulance chasing lawyers with your “join this class action suit now!”  commercials.

I am close to 300 pounds, and I know I gotta do something.  Both working out and  eating better.




4/27/2023 3:58:15 PM EST
[#46]
Quote History
Quoted:
I've been on Trulicity for a couple of years.  Let me tell ya, somedays , the side effects SUCK.  Hasnt helped with weight in years, but it does help even out my BS.
View Quote
My wife got on that about 6 months ago and it has really helped her out.  Her insurance stopped covering it and its like 78-85 a month now on top of all her other drugs.
4/27/2023 6:13:25 PM EST
[#47]
Quote History
Quoted:



Normal caloric restriction weight loss results in a loss of 1lb:4lb ratio of lean mass to adipose and no or almost no loss in bone density.

Dexa scans across several studies with semiglutide use show roughly 40% loss of muscle mass and bone density. You're getting lighter but you're getting fatter. And when you ultimately gain all that fat back your basal metabolism will be even lower than before and a solid sneeze will snap what's left of your spine.
View Quote

I've been doing yard work and getting stronger. I have a mound of dirt in the front yard that I need to put in the back yard using a wheelbarrow. Every day I do this it gets easier.

People use the losing/gaining muscle mass as either an excuse or a fear. I decided to move that dirt because I had a bad cold and hardly moved for a week, and was getting weak. When I mentioned my recent wt gain to my friend she was like "it might be muscle mass"

I've lived weights and gained muscle mass, it too more than one day. After I had several surgeries to fix my knees and shoulder I actually lost weight while getting fatter.

I remember back in the smartwell cookie era, back when fats were villified and the attitude was "you can eat all you want as long as it's not fat and not gain weight". You were also to avoid weighing yourself.

Anyway, I remember sitting in the break room with coworkers stuffing their faces with bagels, rice and smartwell cookies convincing themselves they were not getting fat even though they had grown muffintops. They thought they were gaining muscle mass in spite of not doing a single muscle building exercise.

The mind is extremely prone to the power of suggestion. A lot of smartwell cookies were sold though.

The premise that you can't lose weight and gain or retain muscle mass is typical American pig thinking, thinking that proclaims normally proportioned people are underweight.

In just about every other country males are muscular and wirey all without looking like a bloated tick or eating like a starving dog.

I'm surprised at how much I can do, going long periods without eating. No shakiness, no weakness, no dizziness. Just like before when I adhered to my diet.

I'm confident that when I run out of ozembic, I will have established new habits. It's all about habits.

And AMPK/mTOR cycles but nobody has time to learn about those things, or how beneficial it is to go without food for awhile to let your body enter the clean up phase (AMPK)
4/27/2023 6:36:26 PM EST
[#48]
Keto carnivore with intermittent fasting works better only with no Rx.

Carbs and sugar- stop all of it.

You will lose weight and all your numbers will be good.

Beef butter bacon and eggs has no side effects or experimental drugs.

Go to youtube and look up Dr Ken Berry and Jason fung. Follow what the say and you will be amazed at the results.
4/27/2023 6:46:30 PM EST
[#49]
My A1C has crept up since working night shift/odd sleeping patterns.  I found out I am type 2 in 2015, had my numbers under control with diet until I went third shift and they started creeping up.  I was prescribed Monjauro but it wasn't covered by insurance at the time, so I did Glipazide.  Which did reduced my numbers but I actually gained weight some as it made me ravenously hungry for lunch.  Monjauro has a $25 a month coupon now (found out right here on GD), and I got my scrip filled.  I took my first dose three weeks ago, NO appetite whatsoever within two days of taking it.  Took my second dose last week, started throwing up on the second day.  Was OK the third day, then violent shitting on the next day.  Cost me overtime money for the week, I wasn't going to work sick two days.  Will discuss with my doctor next week when I go for my semiannual.

One thing I found it kept my blood sugar at a very steady number.  You get hungry when it drops, and it never dropped while Monjauro was active in my system.  I know it stimulates insulin production for one thing listed as "how it works"
4/28/2023 10:23:48 AM EST
[#50]
Quote History
Quoted:

I've been doing yard work and getting stronger. I have a mound of dirt in the front yard that I need to put in the back yard using a wheelbarrow. Every day I do this it gets easier.

People use the losing/gaining muscle mass as either an excuse or a fear. I decided to move that dirt because I had a bad cold and hardly moved for a week, and was getting weak. When I mentioned my recent wt gain to my friend she was like "it might be muscle mass"

I've lived weights and gained muscle mass, it too more than one day. After I had several surgeries to fix my knees and shoulder I actually lost weight while getting fatter.

I remember back in the smartwell cookie era, back when fats were villified and the attitude was "you can eat all you want as long as it's not fat and not gain weight". You were also to avoid weighing yourself.

Anyway, I remember sitting in the break room with coworkers stuffing their faces with bagels, rice and smartwell cookies convincing themselves they were not getting fat even though they had grown muffintops. They thought they were gaining muscle mass in spite of not doing a single muscle building exercise.

The mind is extremely prone to the power of suggestion. A lot of smartwell cookies were sold though.

The premise that you can't lose weight and gain or retain muscle mass is typical American pig thinking, thinking that proclaims normally proportioned people are underweight.

In just about every other country males are muscular and wirey all without looking like a bloated tick or eating like a starving dog.

I'm surprised at how much I can do, going long periods without eating. No shakiness, no weakness, no dizziness. Just like before when I adhered to my diet.

I'm confident that when I run out of ozembic, I will have established new habits. It's all about habits.

And AMPK/mTOR cycles but nobody has time to learn about those things, or how beneficial it is to go without food for awhile to let your body enter the clean up phase (AMPK)
View Quote



Short term fasting is great. Eat protein and exercise, specifically weight or resistance training. A magic pill is never the answer.
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