To answer my own question, I did some testing in the woods on my property today. Not my most accurate shooting, but it was all shot standing, off-hand, in fairly low light.
For one, TruGlo TFX Pros (AFAIK there is no Gen 5 specific version of these) do shoot to POA at 10y and 25y on a Gen 5 if you shoot them with POA being the top edge of the front sight intersecting the center of the target.
On the left is my Gen 5 G19's 25y target with the TFX Pros (I do need to drift the rear sight over a little). On the right is the 25y target from my Gen 3 G19 with its OEM plastic Glock sights and a Gen 5 threaded barrel (It has a Grit Grips frame, and the Glock barrel has a Griffin EZ-Lok suppressor mount with a Carry Comp thread protector, but everything else is OEM Glock).
I also tested swapping the OEM barrel in my Gen 5 pistol for a Glock Gen 3 barrel. Both barrels shot to the same POI with the same POA (and interestingly the Gen 3 barrel's group was a slightly smaller). That busts the myth that the Gen 5 Marksman barrel shoots to a different POI than previous gens.
The top right two groups are from the Gen 5 pistol with the Gen 3 barrel.
The left most and center target are from the Gen 5 pistol with it's original Gen 5 barrel.
The bottom target is from the Gen 3 pistol with a Gen 5 threaded barrel.
Both guns and all three OEM Glock barrels shot to POA at 10 yards. 10 shots were fired at each target.