While I'll never go to Africa, my big game rifle is a Ruger No. 1 chambered in 416 Remington Magnum. I'll likely take it out west for elk or moose one day, but that's as far as it'll go. Prior to that I've had a Winchester M70 Safari Express in 416 Rem (I sold this to get the Ruger), a Ruger M77 Alaskan in 416 Ruger, and a CZ 550 American Safari Magnum in .458 Lott. The Lott was just way too much, and I am not recoil shy at all. But the cost of the rounds for it and the recoil was just more than what I could deal with. I loved my Winchester M70 in 416 Rem and I've always loved the Ruger No. 1 as well.
I was lucky enough to find what I think is an unfired No. 1 in 416 Rem Mag just recently, which was one of my grail guns. From what I can tell Ruger only made the 416 Rem Mag No.1s in 2004, so it isn't like the other Tropical calibers where they're pretty available. The seller had mentioned the gun looked unfired but they listed it as used anyways. When I got to my FFL to pick it up the bore was pristine and there were no signs of any brass casing marks on the ejection ramp, so it was either unfired or only fired a couple times at all.