So, about a year ago when I purchased my P227, my buddy was talking about getting an FNX-45 (which he later purchased). Since then we've never had both guns in the same place at the same time. Today, we were both actually able to get to the range and try out the other gun (he tried my P227, while I tried his FNX-45). I ended up only putting about 10 rounds through his FNX, and he put 10 through my P227. The groups that we both shot with the opposite gun were very close to what we were shooting with our own guns. I will say that the FNX does shoot very well, but to me, it was not as comfortable as my P227. The one thing I will note here is after about 150-200 rounds, the takedown lever of the FNX actually got incredibly hot..to the point that you actually needed to change your grip to not index your support hand thumb in that area. The grip on the FNX seemed blocky to me, the grip however was very aggressive, almost too aggressive. If I had been wearing gloves, both of these two issues would have been negated.
Size wise, the two guns actually are VERY close. Here are a few comparison pics. (note: about half way through the pics I changed out my stock barrel to the threaded barrel for a closer comparison. The FNX did not come with the threaded barrel, my friend traded his stock one for the threaded version. The FNX also is using the 15rd extended mags in the photos. I haven't received my P227 extended mags to compare them)
Both pistols are great choices when it comes to a double-stack .45ACP.
The FNX wins in the capacity battle as the "extended mags" do not extend all that far passed the grip and offer 15 rounds versus 10 with the flush fit P227 mags and 14 with the extended.
The P227 wins in terms of after market support and accessories. It took my friend a few months to track down the threaded barrel for his FNX, mine is just a P220 threaded barrel. Also the ability to use P250 45ACP mags and almost all P220 slides gives the P227 a distinct advantage. Not to mention the ability to use a P-SPIT from Gray Guns *cheap plug*
I'd give the nod to the P227 in terms of grip and ergonomics. While the FNX does offer a decocker as well as completely ambidextrous controls, I found the FNX decocker/ safety to not exactly be easy to manipulate (vs a Sig decocker) that could be just a training issue. The P227 will be offering additional grips, which is something that the FNX will not be able to do.
Perceived recoil, I'll give this one to the FNX, but the recoil difference wasn't exactly significant.
Thickness: The FNX slide was much thicker than the P227s, but seeing as these are full sized "combat" pistols which would more likely be carried OWB or in a drop-leg holster, I think that information doesn't really matter all that much.
Weight: According to their official websites the FNX-45 comes in at 33.2oz empty (with mag) and the P227 comes in at 32.0oz empty (with mag)
If you're considering either of these, my advice is to go out and shoot them. You really can't go wrong with either.