Finally had time to get the settings figured out in Reaper (for some reason, input monitoring turned it's self off), and gave it a whirl. I was using my Line 6 UX2 for my interface, and it was ok, but not as good as my Helix. I'm probably going to get a Focusrite Scarlett 2i2. Guys that are using them are saying that Native sounds identical to a regular Helix.
Other than that, great plugin! Every bit as easy to use as any other Helix. And if you want to try it out, the demo is free for 15 days.